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. 2018 Jun;91(2):161-163.
doi: 10.1016/j.diagmicrobio.2018.01.027. Epub 2018 Feb 3.

Prolonged linezolid use is associated with the development of linezolid-resistant Enterococcus faecium

Tiffeny T Smith  1 , Pranita D Tamma  2 , Tiffany B Do  3 , Kathryn E Dzintars  4 , Yuan Zhao  5 , Sara E Cosgrove  6 , Edina Avdic  4
Affiliations

Prolonged linezolid use is associated with the development of linezolid-resistant Enterococcus faecium

Tiffeny T Smith et al. Diagn Microbiol Infect Dis. 2018 Jun.

Abstract

We assessed risk factors for and outcomes of linezolid-resistant vancomycin-resistant Enterococcus faecium (LRVREF) bacteremia over 7 years. Thirty-four LRVREF cases were matched to 68 linezolid-susceptible VREF controls. The odds of bacteremia with LRVREF increased by 7% for each additional day of prior linezolid exposure.

Keywords: Enterococcus faecium; Linezolid-resistant enterococci; VRE.

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