Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep;153(Pt A):21-25.
doi: 10.1016/j.nlm.2018.02.021. Epub 2018 Feb 26.

Memory allocation mechanisms underlie memory linking across time

M Sehgal  1 , M Zhou  1 , A Lavi  1 , S Huang  1 , Y Zhou  2 , A J Silva  3
Affiliations
Review

Memory allocation mechanisms underlie memory linking across time

M Sehgal et al. Neurobiol Learn Mem. 2018 Sep.

Abstract

Memories are dynamic in nature. A cohesive representation of the world requires memories to be altered over time, linked with other memories and eventually integrated into a larger framework of sematic knowledge. Although there is a considerable literature on how single memories are encoded, retrieved and updated, little is known about the mechanisms that govern memory linking, e.g., linking and integration of various memories across hours or days. In this review, we present evidence that specific memory allocation mechanisms, such as changes in CREB and intrinsic excitability, ensure memory storage in ways that facilitate effective recall and linking at a later time. Beyond CREB and intrinsic excitability, we also review a number of other phenomena with potential roles in memory linking.

Keywords: Allocation; CREB; Intrinsic excitability; Memory linking.

PubMed Disclaimer

References

    1. Ballarini F, Moncada D, Martinez MC, Alen N, Viola H. Behavioral tagging is a general mechanism of long-term memory formation. Proc Natl Acad Sci U S A. 2009;106:14599–14604. - PMC - PubMed
    1. Bartlett FC, editor. Remembering: A Study in Experimental and Social Psychology. Cambridge Univeristy Press; 1932.
    1. Benito E, Barco A. CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models. Trends Neurosci. 2010;33:230–240. - PubMed
    1. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016;534:115–118. - PMC - PubMed
    1. Czajkowski R, Jayaprakash B, Wiltgen B, Rogerson T, Guzman-Karlsson MC, Barth AL, Trachtenberg JT, Silva AJ. Encoding and storage of spatial information in the retrosplenial cortex. Proc Natl Acad Sci U S A. 2014;111:8661–8666. - PMC - PubMed

Publication types

Substances