Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 May;104(10):792-793.
doi: 10.1136/heartjnl-2017-312861. Epub 2018 Mar 1.

Is bioprosthetic leaflet thrombosis a trigger to valve degeneration?

Mhairi Katrina Doris  1 , Marc Richard Dweck  1
Affiliations
Editorial

Is bioprosthetic leaflet thrombosis a trigger to valve degeneration?

Mhairi Katrina Doris et al. Heart. 2018 May.
No abstract available

Keywords: aortic stenosis; transcatheter valve interventions.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Possible link between bioprosthetic valve thrombosis and calcification. The study by Del Trigo et al suggests that anticoagulation may preserve transcatheter aortic valve implantation (TAVI) valve haemodynamics. The potential mechanism for this observation is not clear. Concern has recently grown regarding the incidence of subclinical leaflet thrombosis (red arrow) in patients undergoing TAVI, and it is hypothesised that this may lead to future calcific degeneration of bioprosthetic TAVI valves (black arrow). Future research should focus on investigating this possible mechanistic link between bioprosthetic leaflet thrombosis and valve calcification/degeneration and the role that anticoagulant therapy might play in improving TAVI valve durability.
See this image and copyright information in PMC

Comment on

References

    1. Mack MJ, Leon MB, Smith CR, et al. . 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet 2015;385:2477–84. 10.1016/S0140-6736(15)60308-7 - DOI - PubMed
    1. Del Trigo M, Muñoz-García AJ, Latib A, et al. . Impact of anticoagulation therapy on valve haemodynamic deterioration following transcatheter aortic valve replacement. Heart 2018;104:814–820. 10.1136/heartjnl-2017-312514 - DOI - PubMed
    1. Hansson NC, Grove EL, Andersen HR, et al. . Transcatheter aortic valve thrombosis: incidence, predisposing factors, and clinical implocations. J Am Coll Cardiol 2016;68 10.1016/j.jacc.2016.08.010 - DOI - PubMed
    1. Pache G, Schoechlin S, Blanke P, et al. . Early hypo-attenuated leaflet thickening in balloon-expandable transcatheter aortic heart valves. Eur Heart J 2016;37:2263–71. 10.1093/eurheartj/ehv526 - DOI - PubMed
    1. Akahori H, Tsujino T, Naito Y, et al. . Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis. Eur Heart J 2011;32:888–96. 10.1093/eurheartj/ehq479 - DOI - PubMed