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Review
. 2018 Mar 2;19(3):711.
doi: 10.3390/ijms19030711.

Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids

Ho Jun Lee  1 , Yong Ju Jang  2
Affiliations
Review

Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids

Ho Jun Lee et al. Int J Mol Sci. .

Abstract

Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients' quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. In this review, the authors introduce and summarize classical concepts surrounding wound healing and review recent understandings of the biology, prevention and treatment strategies for hypertrophic scars and keloids.

Keywords: hypertrophic scar; keloid; scar biology; scar prevention; scar treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flowchart of the literature search for this review.
Figure 2
Figure 2
Important proteins and cytokines in the wound healing processes. The classical model of wound healing involves three distinct, but overlapping phases that follow a time sequence: the inflammatory, proliferative and remodeling phases. Important cells, proteins and cytokines in each phase are listed.
See this image and copyright information in PMC

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