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. 2018 Mar 1;22(3):283-285.
doi: 10.1016/j.stem.2018.01.019.

Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation

Zaal Kokaia  1 , Olle Lindvall  2
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Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation

Zaal Kokaia et al. Cell Stem Cell. .
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Abstract

In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment.

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