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Comment
. 2018 Mar 1;22(3):285-287.
doi: 10.1016/j.stem.2018.02.006.

Reversing Time: Ezh1 Deficiency Hastens Definitive Hematopoiesis

April C Apostol  1 , Anna E Beaudin  2
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Reversing Time: Ezh1 Deficiency Hastens Definitive Hematopoiesis

April C Apostol et al. Cell Stem Cell. .
Free article

Abstract

The inability to derive multipotent hematopoietic stem cells in vitro stems in part from a limited understanding of how multipotency is acquired during development. Recently in Nature,Vo et al. (2018) reveal the epigenetic enzyme Ezh1 as a master regulator of multipotency during hematopoietic stem cell development.

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  • Regulation of embryonic haematopoietic multipotency by EZH1.
    Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ. Vo LT, et al. Nature. 2018 Jan 25;553(7689):506-510. doi: 10.1038/nature25435. Epub 2018 Jan 17. Nature. 2018. PMID: 29342143 Free PMC article.

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