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Comment
. 2018 Mar 1;22(3):287-289.
doi: 10.1016/j.stem.2018.02.007.

Who Defends the Stem Cell's Citadel?

Hélène Strick-Marchand  1 , David Durantel  2
Affiliations
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Who Defends the Stem Cell's Citadel?

Hélène Strick-Marchand et al. Cell Stem Cell. .
Free article

Abstract

Recently in Cell, Wu et al. (2018) demonstrated that intrinsic expression of a subset of interferon stimulated genes confers resistance to viral infections in stem cells both in vitro and in vivo, while differentiated cells lose this intrinsic gatekeeper expression pattern in favor of inducible interferon responses.

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  • Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
    Wu X, Dao Thi VL, Huang Y, Billerbeck E, Saha D, Hoffmann HH, Wang Y, Silva LAV, Sarbanes S, Sun T, Andrus L, Yu Y, Quirk C, Li M, MacDonald MR, Schneider WM, An X, Rosenberg BR, Rice CM. Wu X, et al. Cell. 2018 Jan 25;172(3):423-438.e25. doi: 10.1016/j.cell.2017.11.018. Epub 2017 Dec 14. Cell. 2018. PMID: 29249360 Free PMC article.
  • Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.
    Chung H, Calis JJA, Wu X, Sun T, Yu Y, Sarbanes SL, Dao Thi VL, Shilvock AR, Hoffmann HH, Rosenberg BR, Rice CM. Chung H, et al. Cell. 2018 Feb 8;172(4):811-824.e14. doi: 10.1016/j.cell.2017.12.038. Epub 2018 Jan 25. Cell. 2018. PMID: 29395325 Free PMC article.

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