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Comment
. 2018 Apr;8(4):384.
doi: 10.1158/2159-8290.CD-RW2018-038. Epub 2018 Mar 2.

A Small-Molecule Splicing Modulator Targets Spliceosome-Mutant Cells

No authors listed
Comment

A Small-Molecule Splicing Modulator Targets Spliceosome-Mutant Cells

No authors listed. Cancer Discov. 2018 Apr.

Abstract

The small molecule H3B-8800 binds to and modulates the SF3b complex to kill spliceosome-mutant cells.

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Comment on

  • H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
    Seiler M, Yoshimi A, Darman R, Chan B, Keaney G, Thomas M, Agrawal AA, Caleb B, Csibi A, Sean E, Fekkes P, Karr C, Klimek V, Lai G, Lee L, Kumar P, Lee SC, Liu X, Mackenzie C, Meeske C, Mizui Y, Padron E, Park E, Pazolli E, Peng S, Prajapati S, Taylor J, Teng T, Wang J, Warmuth M, Yao H, Yu L, Zhu P, Abdel-Wahab O, Smith PG, Buonamici S. Seiler M, et al. Nat Med. 2018 May;24(4):497-504. doi: 10.1038/nm.4493. Epub 2018 Feb 19. Nat Med. 2018. PMID: 29457796 Free PMC article.

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