Advances in glycosylation-mediated cancer-targeted drug delivery

Lulu Cai¹, Zhipeng Gu², Jian Zhong³, Di Wen⁴, Guojun Chen⁴, Lin He⁵, Jun Wu⁶, Zhen Gu⁷

Affiliations

¹ Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. Electronic address: lcai6@ncsu.edu.
² Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510275, China.
³ School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
⁴ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
⁵ Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
⁶ Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: wujun29@mail.sysu.edu.cn.
⁷ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. Electronic address: zgu@email.unc.edu.

PMID: 29501708
DOI: 10.1016/j.drudis.2018.02.009

Review

Advances in glycosylation-mediated cancer-targeted drug delivery

Lulu Cai et al. Drug Discov Today. 2018 May.

. 2018 May;23(5):1126-1138.

doi: 10.1016/j.drudis.2018.02.009. Epub 2018 Feb 28.

Authors

Lulu Cai¹, Zhipeng Gu², Jian Zhong³, Di Wen⁴, Guojun Chen⁴, Lin He⁵, Jun Wu⁶, Zhen Gu⁷

Affiliations

¹ Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. Electronic address: lcai6@ncsu.edu.
² Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510275, China.
³ School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
⁴ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
⁵ Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
⁶ Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: wujun29@mail.sysu.edu.cn.
⁷ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. Electronic address: zgu@email.unc.edu.

PMID: 29501708
DOI: 10.1016/j.drudis.2018.02.009

Abstract

Targeted drug delivery for cancer therapy is expected to enhance therapeutic efficacy with minimized side effects, where the ligand-receptor recognition serves as a common targeting approach. Various ligands have been reported and carbohydrates, one of the crucial structures of tumor cell membranes, have been demonstrated effective for cell-selective binding. Hence, glycosylation-mediated cancer-targeted drug nanocarriers have received increasing attention in recent years. This review surveys a variety of glycosylated drug delivery systems as well as their applications for cancer therapy. Their challenges, opportunities, and future perspectives are also discussed in the end.

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Advances in glycosylation-mediated cancer-targeted drug delivery

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Advances in glycosylation-mediated cancer-targeted drug delivery

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