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Meta-Analysis
. 2019;36(2):111-123.
doi: 10.1159/000487274. Epub 2018 Mar 2.

Systematic Review and Meta-Analysis of Liver Resection for Colorectal Metastases in Elderly Patients

Tim van Tuil  1 , Ali A Dhaif  2 , Wouter W Te Riele  1 , Bert van Ramshorst  1 , Hjalmar C van Santvoort  3
Affiliations
Meta-Analysis

Systematic Review and Meta-Analysis of Liver Resection for Colorectal Metastases in Elderly Patients

Tim van Tuil et al. Dig Surg. 2019.

Abstract

Background: This systematic review and meta-analysis evaluated the short- and long-term outcomes of liver resection for colorectal liver metastases (CRLM) in elderly patients.

Methods: A PubMed, EMBASE, and Cochrane Library search was performed from January 1995 to April 2017, for studies comparing both short- and long-term outcomes in younger and elderly patients undergoing liver resection for CRLM.

Results: Eleven studies comparing patients aged <70 years with patients aged >70 years and 4 studies comparing patients aged <75 years with patients aged >75 years were included. Postoperative morbidity was similar in patients aged >70 years (27 vs. 30%; p = 0.35) but higher in patients aged >75 years (21 vs. 32%; p = 0.001). Postoperative mortality was higher in both patients aged >70 years (2 vs. 4%; p = 0.01) and in patients aged >75 years (1 vs. 6%; p = 0.02). Mean 5-year overall survival was lower in patients aged >70 years (40 vs. 32%; p < 0.001) but equal in patients aged >75 years (42 vs. 32%; p = 0.06).

Conclusion: Although postoperative morbidity and mortality were increased with higher age, liver resection for CRLM seems justified in selected elderly patients.

Keywords: Cancer; Liver; Surgery.

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