Review
doi: 10.1016/j.otc.2017.11.002.
Otosclerosis: From Genetics to Molecular Biology
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- PMID: 29502723
- DOI: 10.1016/j.otc.2017.11.002
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Review
Otosclerosis: From Genetics to Molecular Biology
Otolaryngol Clin North Am.
2018 Apr.
Abstract
Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
Keywords: Gene; Genetics; Otic capsule; Otosclerosis; Pathophysiology.
Copyright © 2017 Elsevier Inc. All rights reserved.
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