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. 1979;53(1):5-16.
doi: 10.1007/BF00289443.

Chromosomes in acute leukemia

E L Prigogina, E W Fleischman, G P Puchkova, O E Kulagina, S A Majakova, S A Balakirev, M A Frenkel, N V Khvatova, I S Peterson

Chromosomes in acute leukemia

E L Prigogina et al. Hum Genet. 1979.

Abstract

The karyotype of leukemic cells of 78 acute leukemia patients (37 ANLL, 34ALL, and 7 of unknown type) was studied by means of G-banding. Chromosomal abnormalities were found in 50 patients (72%). Chromosomes 8,21,5,7,11, and 19 were preferentially involved in the abnormalities, both in ANLL and in ALL. A high incidence of the characteristic rearrangement t(8;21) was noted in AML: (in 6 of 22 AMP patients). An identical reciprocal translocation--t(4;11)--was seen in 4 out of 34 ALL patients.

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References

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