Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder

doi:10.4088/JCP.17l11824

Controlled Clinical Trial

. 2018 Jan/Feb;79(1):17l11824.

doi: 10.4088/JCP.17l11824.

Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder

Omer Linkovski¹, Hanyang Shen¹, Jordana Zwerling¹, Maria Filippou-Frye¹, Booil Jo¹, Elisabeth Cordell¹, Thomas B Cooper², Helen Blair Simpson^{3

4}, Ronald M Burch⁵, Joseph R Moskal^{5

6}, Francis Lee⁷, Carolyn I Rodriguez^{8

1

9}

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
² Analytical Psychopharmacology Laboratory, Nathan Kline Institute, Research Foundation for Mental Hygiene of New York State, Orangeburg, New York, USA.
³ Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
⁴ New York State Psychiatric Institute, New York, New York, USA.
⁵ Aptinyx, Inc, Evanston, Illinois, USA.
⁶ The Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Illinois, USA.
⁷ Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA.
⁸ carolynrodriguez@stanford.edu.
⁹ Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.

PMID: 29505186
PMCID: PMC7370843
DOI: 10.4088/JCP.17l11824

Controlled Clinical Trial

Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder

Omer Linkovski et al. J Clin Psychiatry. 2018 Jan/Feb.

. 2018 Jan/Feb;79(1):17l11824.

doi: 10.4088/JCP.17l11824.

Authors

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
² Analytical Psychopharmacology Laboratory, Nathan Kline Institute, Research Foundation for Mental Hygiene of New York State, Orangeburg, New York, USA.
³ Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
⁴ New York State Psychiatric Institute, New York, New York, USA.
⁵ Aptinyx, Inc, Evanston, Illinois, USA.
⁶ The Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Illinois, USA.
⁷ Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA.
⁸ carolynrodriguez@stanford.edu.
⁹ Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.

PMID: 29505186
PMCID: PMC7370843
DOI: 10.4088/JCP.17l11824

No abstract available

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest: Dr Simpson has received royalties from Cambridge University Press and UpToDate. Dr Moskal was founder of and owned stock in Naurex, and Dr Burch was an employee at Naurex when rapastinel was donated for the current study. Dr Rodriguez received rapastinel for the current study at no cost and is a consultant for Allergan, BlackThorn Therapeutics, and Rugen Therapeutics. Drs Linkovski, Filippou-Frye, Jo, and Lee; Mss Shen, Zwerling, and Cordell; and Mr Cooper report no additional financial or other relationships relevant to the subject of this letter.

Figures

**Figure 1.. Serum BDNF Levels at Baseline and 40,110, and 230 Minutes After a Single Infusion of Rapastinel or Ketamine**
^aMean distribution of serum BDNF levels as a function of time. Error bars represent 1 standard error from the mean. *P<.05. Abbreviation: BDNF = brain-derived neurotrophic factor.

See this image and copyright information in PMC

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References

1. Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry. 2008;64(6):527–532. - PMC - PubMed
1. Polyakova M, Stuke K, Schuemberg K, et al. BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J Affect Disord. 2015;174:432–440. - PubMed
1. Bandelow B, Baldwin D, Abelli M, et al. Biological markers for anxiety disorders, OCD and PTSD: a consensus statement, part II: neurochemistry, neurophysiology and neurocognition. World J Biol Psychiatry. 2017;18(3):162–214. - PMC - PubMed
1. Maina G, Rosso G, Zanardini R, et al. Serum levels of brain-derived neurotrophic factor in drug-naive obsessive-compulsive patients: a case-control study. J Affect Disord. 2010;122(1–2):174–178. - PubMed
1. Lepack AE, Bang E, Lee B, et al. Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures. Neuropharmacology. 2016;111:242–252. - PMC - PubMed

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[1] Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry. 2008;64(6):527–532. - PMC - PubMed

[2] Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry. 2008;64(6):527–532. - PMC - PubMed

[3] Polyakova M, Stuke K, Schuemberg K, et al. BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J Affect Disord. 2015;174:432–440. - PubMed

[4] Polyakova M, Stuke K, Schuemberg K, et al. BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J Affect Disord. 2015;174:432–440. - PubMed

[5] Bandelow B, Baldwin D, Abelli M, et al. Biological markers for anxiety disorders, OCD and PTSD: a consensus statement, part II: neurochemistry, neurophysiology and neurocognition. World J Biol Psychiatry. 2017;18(3):162–214. - PMC - PubMed

[6] Bandelow B, Baldwin D, Abelli M, et al. Biological markers for anxiety disorders, OCD and PTSD: a consensus statement, part II: neurochemistry, neurophysiology and neurocognition. World J Biol Psychiatry. 2017;18(3):162–214. - PMC - PubMed

[7] Maina G, Rosso G, Zanardini R, et al. Serum levels of brain-derived neurotrophic factor in drug-naive obsessive-compulsive patients: a case-control study. J Affect Disord. 2010;122(1–2):174–178. - PubMed

[8] Maina G, Rosso G, Zanardini R, et al. Serum levels of brain-derived neurotrophic factor in drug-naive obsessive-compulsive patients: a case-control study. J Affect Disord. 2010;122(1–2):174–178. - PubMed

[9] Lepack AE, Bang E, Lee B, et al. Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures. Neuropharmacology. 2016;111:242–252. - PMC - PubMed

[10] Lepack AE, Bang E, Lee B, et al. Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures. Neuropharmacology. 2016;111:242–252. - PMC - PubMed

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Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder

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Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder

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