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. 2018 May;226(5):719-729.
doi: 10.1016/j.jamcollsurg.2018.02.004. Epub 2018 Mar 2.

Microbiome Medicine: This Changes Everything

John C Alverdy  1
Affiliations

Microbiome Medicine: This Changes Everything

John C Alverdy. J Am Coll Surg. 2018 May.
No abstract available

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Figures

Figure 1
Figure 1
Multiple life-style inputs into the microbiome-host interactome that can shape an individual’s immune response to surgical injury. MAP, mitogen-activated protein; NSAIDs, non-steroidal anti-inflammatory drugs; PAMPs, pathogen associated molecular patterns; PRR, pathogen related receptor; TNF, tumor necrosis factor.
Figure 2
Figure 2
Proposed mechanism by which the intestinal microbiome influences the host response to surgical injury. (A) Sequence of events by which surgical injury leads to a pathoadaptive response of the microbiome adversely affecting the recovery process. (B) Potential mechanisms by which enhanced recovery programs after surgery (ERAS) lead to a state of molecular détente between the host and its microbiome and promote recovery. MAP, mitogen-activated protein; PAMPs, pathogen associated molecular patterns; PRR, pathogen related receptor, SSI, surgical site infection; TNF, tumor necrosis factor.
Figure 2
Figure 2
Proposed mechanism by which the intestinal microbiome influences the host response to surgical injury. (A) Sequence of events by which surgical injury leads to a pathoadaptive response of the microbiome adversely affecting the recovery process. (B) Potential mechanisms by which enhanced recovery programs after surgery (ERAS) lead to a state of molecular détente between the host and its microbiome and promote recovery. MAP, mitogen-activated protein; PAMPs, pathogen associated molecular patterns; PRR, pathogen related receptor, SSI, surgical site infection; TNF, tumor necrosis factor.
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