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Meta-Analysis
. 2018 Mar 5;13(1):48.
doi: 10.1186/s13018-018-0747-8.

Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis

Ran Ma  1 , Guan-Hong Chen  1 , Liu-Jing Zhao  1 , Xi-Cheng Zhai  2
Affiliations
Meta-Analysis

Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis

Ran Ma et al. J Orthop Surg Res. .

Abstract

Background: This meta-analysis aimed to assess whether the specific nonsteroidal anti-inflammatory drug (NSAID) naproxen has a role in reducing the occurrence of heterotopic ossification after hip surgery.

Methods: Potential studies were identified in the following electronic databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Google. We included studies involving hip surgery patients in which the intervention group received naproxen and the control group received placebo. The occurrence of heterotopic ossification and complications were the final outcomes. Stata 13.0 was used for the meta-analysis.

Results: Four randomized controlled trials (RCTs) involving 269 patients were ultimately included in this meta-analysis. The use of naproxen was associated with a significant reduction in the occurrence of heterotopic ossification at 1.5-, 3-, 6-, and 12-month follow-ups (P < 0.05). There was no significant difference in the occurrence of complications between treatment and control groups (P > 0.05).

Conclusion: Our analysis indicates that naproxen can decrease the occurrence of heterotopic ossification without increasing complications in hip surgery patients. Due to the limited number of studies included, more high-quality RCTs are needed to identify the optimal dose of naproxen.

Keywords: Heterotopic ossification; Hip surgery; Meta-analysis; Naproxen.

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Conflict of interest statement

Author contributions

RM and GHC conceived the study design. LJZ and XCZ performed the study, collected the data, and contributed to the study design. LJZ and XCZ prepared the manuscript. RM, GHC, and XCZ edited the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

None

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
PRISMA flowchart for the included studies
Fig. 2
Fig. 2
Risk of bias summary for the included studies
Fig. 3
Fig. 3
Risk of bias graph for the included studies
Fig. 4
Fig. 4
Forest plot comparing the occurrence of HO at 1.5 months after surgery between the two groups
Fig. 5
Fig. 5
Forest plot comparing the occurrence of HO at 3 months after surgery between the two groups
Fig. 6
Fig. 6
Forest plot comparing the occurrence of HO at 6 months after surgery between the two groups
Fig. 7
Fig. 7
Forest plot comparing the occurrence of HO at 12 months after surgery between the two groups
Fig. 8
Fig. 8
Forest plot comparing the occurrence of complications after surgery between the two groups
See this image and copyright information in PMC

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