Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Mar 5;13(1):47.
doi: 10.1186/s13018-018-0750-0.

Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis

Huihong Wu  1 , Siting Wang  1 , Weiyou Chen  1 , Xinli Zhan  1 , Zengming Xiao  1 , Hua Jiang  2 , Qingjun Wei  3
Affiliations
Meta-Analysis

Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis

Huihong Wu et al. J Orthop Surg Res. .

Abstract

Background: An increasing number of studies have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene polymorphisms and the risk of lumbar disc degeneration (LDD). However, these studies have yielded contradictory results. The purpose of this meta-analysis is to investigate the association between the collagen IX gene polymorphisms (rs12077871, rs12722877, rs7533552 in COL9A2; rs61734651 in COL9A3) and LDD.

Methods: All relevant articles were collected from PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). The last electronic search was performed on September 1, 2017. The allele/genotype frequencies were extracted from each study. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of associations under the five comparison genetic models. Statistical analysis was performed by Review Manager (RevMan) 5.31 software.

Results: The meta-analysis of 10 case-control studies, including 2102 LDD cases and 2507 controls, indicated that COL9A2 gene (rs12077871, rs12722877, rs7533552) and COL9A3 gene (rs61734651) polymorphisms were not associated with LDD (rs12077871: T vs. C, OR = 1.85, 95% CI = 0.87-3.91, P = 0.11; rs12722877: G vs. C, OR = 0.83, 95% CI = 0.69-1.01, P = 0.06; rs7533552: G vs. A, OR = 1.11, 95% CI = 0.98-1.25, P = 0.09; rs61734651: T vs. C, OR = 1.57, 95% CI = 0.51-4.84, P = 0.43). The Egger text and the Begg funnel plot did not show any evidence of publication bias.

Conclusion: rs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 were not significantly associated with a predisposition to LDD. Large-scale and well-designed studies are needed to confirm this conclusion.

Keywords: COL9A2; COL9A3; Lumbar disc disease; Meta-analysis; Polymorphisms.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Literature search flow diagram
Fig. 2
Fig. 2
Forest plot of the pooled ORs with 95% CIs for associations between COL9A2 rs12077871 and LDD in overall populations under the allelic contrast model (C vs. T allele); events: the number of C allele
Fig. 3
Fig. 3
Forest plot of the pooled ORs with 95% CIs for associations between COL9A2 rs12722877 and LDD in overall populations under the allelic contrast model (C vs. G allele); events: the number of C allele
Fig. 4
Fig. 4
Forest plot of the pooled ORs with 95% CIs for associations between COL9A2 rs7533552 and LDD in overall populations under the allelic contrast model (A vs. G allele); events: the number of A allele
Fig. 5
Fig. 5
Forest plot of the pooled ORs with 95% CIs for associations between COL9A3 rs61734651 and LDD in overall populations under the allelic contrast model (T vs. C allele); events: the number of C allele
Fig. 6
Fig. 6
Funnel plot analysis for publication bias; COL9A2 gene polymorphism (rs7533552) under the allelic contrast model
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Shmagel A, Foley R, Ibrahim H. Epidemiology of chronic low back pain in US adults: data from the 2009–2010 National Health and Nutrition Examination Survey. Arthritis Care Res (Hoboken) 2016;68:1688–1694. doi: 10.1002/acr.22890. - DOI - PMC - PubMed
    1. Vassilaki M, Hurwitz EL. Insights in public health: perspectives on pain in the low back and neck: global burden, epidemiology, and management. Hawaii J Med Public Health. 2014;73:122–126. - PMC - PubMed
    1. Joud A, Petersson IF, Englund M. Low back pain: epidemiology of consultations. Arthritis Care Res (Hoboken) 2012;64:1084–1088. - PubMed
    1. Annunen S, Paassilta P, Lohiniva J, Perala M, Pihlajamaa T, Karppinen J, Tervonen O, Kroger H, Lahde S, Vanharanta H, et al. An allele of COL9A2 associated with intervertebral disc disease. Science. 1999;285:409–412. doi: 10.1126/science.285.5426.409. - DOI - PubMed
    1. Kawaguchi Y, Kanamori M, Ishihara H, Ohmori K, Matsui H, Kimura T. The association of lumbar disc disease with vitamin-D receptor gene polymorphism. J Bone Joint Surg Am. 2002;84-A:2022–2028. doi: 10.2106/00004623-200211000-00018. - DOI - PubMed