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Review
. 2018 Mar;4(3):172-175.
doi: 10.1016/j.trecan.2018.01.005. Epub 2018 Feb 23.

CSB: An Emerging Actionable Target for Cancer Therapy

Luca Proietti-De-Santis  1 , Alessio Balzerano  2 , Giorgio Prantera  2
Affiliations
Review

CSB: An Emerging Actionable Target for Cancer Therapy

Luca Proietti-De-Santis et al. Trends Cancer. 2018 Mar.

Abstract

The DNA repair protein Cockayne syndrome group B (CSB) is frequently found overexpressed in cancer cells. High CSB levels favor tumor cell proliferation whilst inhibiting apoptosis. Conversely, the suppression of CSB has significant anticancer effects. In this manuscript we describe CSB downregulation as a potential new therapeutic approach in cancer.

Keywords: Cockayne syndrome B protein; ER stress; cancer therapy; hypoxia; p53; transcription coupled repair.

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