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Review
. 2018 Mar;4(3):222-238.
doi: 10.1016/j.trecan.2017.12.008. Epub 2018 Feb 9.

MicroRNA-Based Drugs for Brain Tumors

Shubaash Anthiya  1 , Audrey Griveau  2 , Claire Loussouarn  3 , Patrick Baril  4 , Martin Garnett  5 , Jean-Paul Issartel  6 , Emmanuel Garcion  7
Affiliations
Review

MicroRNA-Based Drugs for Brain Tumors

Shubaash Anthiya et al. Trends Cancer. 2018 Mar.

Abstract

MicroRNAs (miRNAs) are key regulatory elements encoded by the genome. A single miRNA can downregulate the expression of multiple genes involved in diverse functions. Because cancer is a disease with multiple gene aberrations, developing novel approaches to identify and modulate miRNA pathways may result in a breakthrough for cancer treatment. With a special focus on glioblastoma (GBM), this review provides an up-to-date summary of miRNA biogenesis, the role of miRNA in cancer resistance, and essential tools for modulating miRNA expression, as well as of clinically promising RNAi delivery systems and how they can be adapted for therapy.

Keywords: RNAi; argonaute; brain targeting; cancer resistance; drug delivery; exosomes; glioblastoma; nanoparticles.

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