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. 2017 Oct;34(5):457-463.
doi: 10.5114/ada.2017.71112. Epub 2017 Oct 31.

Antihistamines in the treatment of pruritus in psoriasis

Anna Domagała  1 , Jacek Szepietowski  2 , Adam Reich  2   3
Affiliations

Antihistamines in the treatment of pruritus in psoriasis

Anna Domagała et al. Postepy Dermatol Alergol. 2017 Oct.

Abstract

Aim: To evaluate the efficacy of antihistamines in reducing pruritus in psoriasis, 61 patients were randomized to be treated for 1 week with clemastine (n = 20), levocetirizine (n = 21) or placebo (n = 20).

Material and methods: All patients received the same routine antipsoriatic treatment. Itch intensity was assessed with VAS and the Itch Questionnaire, and hand movements during sleep were counted with an accelerometer.

Results: There was a statistically significant decrease in mean VAS scoring in clemastine and levocetirizine groups (p < 0.001), but not in the placebo group. Questionnaire scoring decreased significantly during the study in all study groups, with the greatest improvement noted in the clemastine group. The number of wrist movements during sleep did not differ significantly between groups.

Conclusions: Antihistamines of the first and second generations seem to be effective in reducing itch in patients with psoriasis, albeit the antipruritic effect is rather moderate. These observations need to be confirmed on larger patient groups.

Keywords: antihistamines; pruritus; psoriasis.

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Figures

Figure 1
Figure 1
Relative change of the visual analog scoring in the treated groups
Figure 2
Figure 2
Relative change of Itch Questionnaire scoring in the treated groups
See this image and copyright information in PMC

References

    1. Langley RG, Krueger GG, Griffiths CE. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis. 2005;64:18–23. - PMC - PubMed
    1. Reich A, Hrehorów E, Szepietowski JC. Pruritus is an important factor negatively influencing the well-being of psoriatic patients. Acta Derm Venereol. 2010;90:257–63. - PubMed
    1. Amatya B, Wennersten G, Nordlind K. Patients’ perspective of pruritus in chronic plaque psoriasis: a questionnaire-based study. J Eur Acad Dermatol Venereol. 2008;22:822–6. - PubMed
    1. Yosipowitch G, Goon A, Wee J, et al. The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis. Br J Dermatol. 2000;143:969–73. - PubMed
    1. Szepietowski JC, Reich A, Wiśnicka B. Itching in patients suffering from psoriasis. Acta Dermatovenerol Croat. 2002;10:221–6. - PubMed