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. 2018 Feb 24;8(1):13-22.
doi: 10.5500/wjt.v8.i1.13.

Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients

Giulio Sergio Roi  1 , Giovanni Mosconi  2 , Valentina Totti  3 , Maria Laura Angelini  2 , Erica Brugin  4 , Patrizio Sarto  5 , Laura Merlo  5 , Sergio Sgarzi  6 , Michele Stancari  6 , Paola Todeschini  7 , Gaetano La Manna  7 , Andrea Ermolao  8 , Ferdinando Tripi  9 , Lucia Andreoli  9 , Gianluigi Sella  10 , Alberto Anedda  11 , Laura Stefani  12 , Giorgio Galanti  12 , Rocco Di Michele  3 , Franco Merni  3 , Manuela Trerotola  13 , Daniela Storani  13 , Alessandro Nanni Costa  13
Affiliations

Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients

Giulio Sergio Roi et al. World J Transplant. .

Abstract

Aim: To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations.

Methods: Ninety-nine kidney transplant recipients (KTRs) were assigned to interventional exercise (Group A; n = 52) and a usual care cohort (Group B; n = 47). Blood and urine chemistry, exercise capacity, muscular strength, anthropometric measures and health-related quality of life (HRQoL) were assessed at baseline, and after 6 and 12 mo. Group A underwent a supervised training three times per week for 12 mo. Group B received only general recommendations about home-based physical activities.

Results: Eighty-five KTRs completed the study (Group A, n = 44; Group B, n = 41). After 12 mo, renal function remained stable in both groups. Group A significantly increased maximum workload (+13 W, P = 0.0003), V'O2 peak (+3.1 mL/kg per minute, P = 0.0099), muscular strength in plantar flexor (+12 kg, P = 0.0368), height in the countermovement jump (+1.9 cm, P = 0.0293) and decreased in Body Mass Index (-0.5 kg/m2, P = 0.0013). HRQoL significantly improved in physical function (P = 0.0019), physical-role limitations (P = 0.0321) and social functioning scales (P = 0.0346). No improvements were found in Group B.

Conclusion: Twelve-month of supervised aerobic and resistance training improves the physiological variables related to physical fitness and cardiovascular risks without consequences on renal function. Recommendations alone are not sufficient to induce changes in exercise capacity of KTRs. Our study is an example of collaborative working between transplant centres, sports medicine and exercise facilities.

Keywords: Aerobic exercise; Kidney transplant recipients; Muscle strength; Renal function; Supervised exercise.

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Conflict of interest statement

Conflict-of-interest statement: Dr. Nanni Costa has nothing to disclose.

References

    1. Varghese T, Schultz WM, McCue AA, Lambert CT, Sandesara PB, Eapen DJ, Gordon NF, Franklin BA, Sperling LS. Physical activity in the prevention of coronary heart disease: implications for the clinician. Heart. 2016;102:904–909. - PubMed
    1. Samitz G, Egger M, Zwahlen M. Domains of physical activity and all-cause mortality: systematic review and dose-response meta-analysis of cohort studies. Int J Epidemiol. 2011;40:1382–1400. - PubMed
    1. Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA. 2009;301:2024–2035. - PubMed
    1. Riess KJ, Haykowsky M, Lawrance R, Tomczak CR, Welsh R, Lewanczuk R, Tymchak W, Haennel RG, Gourishankar S. Exercise training improves aerobic capacity, muscle strength, and quality of life in renal transplant recipients. Appl Physiol Nutr Metab. 2014;39:566–571. - PubMed
    1. Kohl HW, Craig CL, Lambert EV, Inoue S, Alkandari JR, Leetongin G, Kahlmeier S; Lancet Physical Activity Series Working Group. The pandemic of physical inactivity: global action for public health. Lancet. 2012;380:294–305. - PubMed