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. 2018 Mar;64(3):440-448.
doi: 10.1007/s12031-018-1040-3. Epub 2018 Mar 5.

Relative Abundance of Proteins in Blood Plasma Samples from Patients with Chronic Cerebral Ischemia

Anna L Kaysheva  1 , Artur T Kopylov  2 , Elena A Ponomarenko  2 , Olga I Kiseleva  2 , Nadezhda B Teryaeva  3 , Alexander A Potapov  3 , Alexander А Izotov  2 , Sergei G Morozov  4 , Valeria Yu Kudryavtseva  5 , Alexander I Archakov  2
Affiliations

Relative Abundance of Proteins in Blood Plasma Samples from Patients with Chronic Cerebral Ischemia

Anna L Kaysheva et al. J Mol Neurosci. 2018 Mar.

Abstract

A comparative protein profile analysis of 17 blood plasma samples from patients with ischemia and 20 samples from healthy volunteers was carried out using ultra-high resolution mass spectrometry. The analysis of measurements was performed using the proteomics search engine OMSSA. Normalized spectrum abundance factor (NSAF) in the biological samples was assessed using SearchGUI. The findings of mass spectrometry analysis of the protein composition of blood plasma samples demonstrate that the depleted samples are quite similar in protein composition and relative abundance of proteins. By comparing them with the control samples, we have found a small group of 44 proteins characteristic of the blood plasma samples from patients with chronic cerebral ischemia. These proteins contribute to the processes of homeostasis maintenance, including innate immune response unfolding, the response of a body to stress, and contribution to the blood clotting cascade.

Keywords: Chronic cerebral ischemia; LFQ; Panoramic mass spectrometry; Protein markers.

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