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Review
. 2018 May;66(5):716-719.
doi: 10.1097/MPG.0000000000001948.

Induced Pluripotent Stem Cell-Derived Hepatocytes and Precision Medicine in Human Liver Disease

Sakil Kulkarni  1 , David A Rudnick  1   2
Affiliations
Review

Induced Pluripotent Stem Cell-Derived Hepatocytes and Precision Medicine in Human Liver Disease

Sakil Kulkarni et al. J Pediatr Gastroenterol Nutr. 2018 May.

Abstract

Liver-like human cells can be generated from human skin by converting fibroblasts to "induced pluripotent stem cells" (iPSCs), then differentiating the iPSCs into "induced hepatocytes". Although still primarily used as a research tool, emerging applications involving iPSC-derived induced hepatocytes have exciting and provocative clinical and translational potential. This review provides a brief summary of the current status of this field and obstacles that must be overcome before this novel tool will enable precision medicine-based approaches to human liver disease.

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