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Comment
. 2018 Mar 6;24(3):258-259.
doi: 10.1038/nm.4510.

A previously undetected pathology of Zika virus infection

Kimberly M Christian  1 , Hongjun Song  1   2   3 , Guo-Li Ming  1   2
Affiliations
Comment

A previously undetected pathology of Zika virus infection

Kimberly M Christian et al. Nat Med. .

Abstract

In a nonhuman primate model of Zika virus infection, structural and cellular pathology deficits that could have a long-lasting impact on neural development and neurocognitive function are detected in offspring of infected mothers.

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
In utero exposure to ZIKV perturbs fetal brain development. (a) Adams Waldorf et al. inoculated pregnant pigtail macaques with either a Cambodian or Brazilian strain of ZIKV at different time points in the gestational period, which led to gliosis that was more pronounced following later-stage infections and gradual decline in the relative volume of noncortical regions after 100 d in utero. (b) Adams Waldorf et al. identify abnormal histopathology observed in neurogenic regions, including the subgranular zone (SGZ) (left), which shows disorganized neural stem cells and immature granule neurons and a loss of neuronal progenitors, and the subventricular zone (SVZ) (right), which shows a loss of ependymal cells, fusion of ventricular surfaces, decreased cell proliferation, and increased gliosis.
See this image and copyright information in PMC

Comment on

  • Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain.
    Adams Waldorf KM, Nelson BR, Stencel-Baerenwald JE, Studholme C, Kapur RP, Armistead B, Walker CL, Merillat S, Vornhagen J, Tisoncik-Go J, Baldessari A, Coleman M, Dighe MK, Shaw DWW, Roby JA, Santana-Ufret V, Boldenow E, Li J, Gao X, Davis MA, Swanstrom JA, Jensen K, Widman DG, Baric RS, Medwid JT, Hanley KA, Ogle J, Gough GM, Lee W, English C, Durning WM, Thiel J, Gatenby C, Dewey EC, Fairgrieve MR, Hodge RD, Grant RF, Kuller L, Dobyns WB, Hevner RF, Gale M Jr, Rajagopal L. Adams Waldorf KM, et al. Nat Med. 2018 Mar;24(3):368-374. doi: 10.1038/nm.4485. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400709 Free PMC article.

References

    1. Ming GL, Tang H & Song H Cell Stem Cell 19, 690–702 (2016). - PMC - PubMed
    1. Tang H et al. Cell Stem Cell 18, 587–590 (2016). - PMC - PubMed
    1. Qian X et al. Cell 165, 1238–1254 (2016). - PMC - PubMed
    1. Li C et al. Cell Stem Cell 19, 120–126 (2016). - PubMed
    1. Adams Waldorf KM et al. Nat. Med 22, 1256–1259 (2016). - PMC - PubMed