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. 1987 Mar 15;43(3):324-7.
doi: 10.1007/BF01945570.

Cyclosporin A enhances streptozocin-induced diabetes in CD-1 mice

R Iwakiri, S Nagafuchi, E Kounoue, S Nakano, T Koga, M Nakayama, M Nakamura, Y Niho

Cyclosporin A enhances streptozocin-induced diabetes in CD-1 mice

R Iwakiri et al. Experientia. .

Abstract

Cyclosporin A (CYA), when administered to CD-1 mice treated with a subdiabetogenic dose of Streptozocin (STZ), exacerbated the STZ-induced insulitis and elevated the plasma glucose levels, parallel to a reduction of the insulin content of the pancreas. The possible mechanisms of CYA-mediated aggravation of STZ-induced diabetes are discussed.

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