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Comment
. 2018 Mar 6;27(3):487-488.
doi: 10.1016/j.cmet.2018.02.015.

High Cholesterol at the Heart of Phagolysosomal Damage

Andrew P Lieberman  1 , Joel A Swanson  2
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Free article
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High Cholesterol at the Heart of Phagolysosomal Damage

Andrew P Lieberman et al. Cell Metab. .
Free article

Abstract

Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation, damaged phagolysosomes, and limited tissue repair.

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