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Review
. 2018 Feb 22;9(1):15-20.
doi: 10.1007/s13167-018-0127-9. eCollection 2018 Mar.

Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine

Olga Golubnitschaja  1   2   3 , Josef Flammer  4
Affiliations
Review

Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine

Olga Golubnitschaja et al. EPMA J. .

Abstract

This case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation of the individualised patient profile. The authors emphasise the great clinical relevance of the FS and field-related research.

Keywords: Cancer; Diagnosis; Flammer syndrome; Multi-level diagnostics; Predictive preventive personalised medicine; Pregnancy; Recommendations; Risk assessment.

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Conflict of interest statement

Compliance with ethical standardsAll procedures performed in this study were in accordance with the ethical standards of and with the permission (the reference number is 090/16) by the research committee of Rheinische Friedrich-Wilhelms-Universität Bonn and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The patient was informed about the purposes of the study and consequently has signed the “consent of the patient”. The authors declare that they have no conflict of interest.All procedures performed in the current study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.No experiments have been performed including patients and/or animals.

References

    1. Konieczka K, Ritch R, Traverso CE, Kim DM, Kook MS, Gallino A, Golubnitschaja O, Erb C, Reitsamer HA, Kida T, Kurysheva N, Yao K. Flammer syndrome. EPMA J. 2014;5(1):11. doi: 10.1186/1878-5085-5-11. - DOI - PMC - PubMed
    1. Avishai E, Yeghiazaryan K, Golubnitschaja O. Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine. EPMA J. 2017;8(1):23–33. doi: 10.1007/s13167-017-0081-y. - DOI - PMC - PubMed
    1. Flammer J, Konieczka K. The discovery of the Flammer syndrome: a historical and personal perspective. EPMA J. 2017;8(2):75–97. doi: 10.1007/s13167-017-0090-x. - DOI - PMC - PubMed
    1. Konieczka K, Flammer J. Phenomenology and clinical relevance of the Flammer syndrome. Klin Monatsbl Augenheilkd. 2016;233(12):1331–1336. doi: 10.1055/s-0042-118881. - DOI - PubMed
    1. Golubnitschaja O, Debald M, Yeghiazaryan K, Kuhn W, Pešta M, Costigliola V, Grech G. Breast cancer epidemic in the early 21st century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumor Biol. 2016;37(10):12941–12957. doi: 10.1007/s13277-016-5168-x. - DOI - PubMed

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