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Review
. 2017 Oct 10:28:127.
doi: 10.11604/pamj.2017.28.127.13640. eCollection 2017.

[Occult hepatitis B reactivation in a patient with homozygous sickle cell disease: clinical case and literature review]

[Article in French]
Moustapha Diop  1 , Viviane Marie Pierre Cisse-Diallo  1 , Daye Ka  1 , Ndèye Aissatou Lakhe  1 , Khardiata Diallo-Mbaye  1 , Aminata Massaly  1 , Alassane Dièye  1 , Ndèye Maguette Fall  1 , Aboubacar Sadikh Badiane  1 , Daouda Thioub  1 , Louise Fortes-Déguénonvo  1 , Gora Lo  2 , Cheikh Tacko Diop  3 , Cheikh Tidiane Ndour  1 , Masserigne Soumaré  1 , Moussa Seydi  1
Affiliations
Review

[Occult hepatitis B reactivation in a patient with homozygous sickle cell disease: clinical case and literature review]

[Article in French]
Moustapha Diop et al. Pan Afr Med J. .

Abstract
in English, French

Occult Hepatitis B corresponds to the presence of hepatitis B virus-deoxyribonucleic acid (HBV-DNA) in serum and/or in liver of a patient despite HBsAg negativity. Clinically, it is usually asymptomatic. Its reactivation is rare and commonly occurs in immunosuppressed individuals. We report the case of a 21-year old patient from Senegal, with homozygous sickle cell disease, presenting with cholestatic jaundice. Laboratory tests showed reactivation of occult Hepatitis B. This study emphasizes the need to systematically investigate the presence of occult Hepatitis B in patients with sickle cell disease suffering from acute liver disease.

L'hépatite B occulte correspond à la présence de l'ADN du virus de l'hépatite B dans le sérum et/ou dans le foie d'un patient malgré la négativité de l'AgHBs. C'est une forme clinique habituellement asymptomatique. Sa réactivation est rare et survient en général chez le sujet immunodéprimé. Nous rapportons un cas d'un patient sénégalais de 21 ans, drépanocytaire homozygote, qui présentait un ictère de type cholestatique chez qui l'exploration biologique concluait a une réactivation d'une hépatite B occulte. Cette observation souligne la nécessité de rechercher systématiquement une réactivation d'une hépatite B occulte devant toute hépatopathie aigue chez le drépanocytaire.

Keywords: Occult Hepatitis B; homozygous sickle cell disease; reactivation.

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Figures

Figure 1
Figure 1
Evolution des transaminases et de l’ADN du VHB en fonction du temps
See this image and copyright information in PMC

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