TREM2 and Amyloid Beta: A Love-Hate Relationship

Joe Udeochu¹, Faten A Sayed², Li Gan³

Affiliations

¹ Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
² Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
³ Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA. Electronic address: lgan@gladstone.ucsf.edu.

PMID: 29518360
DOI: 10.1016/j.neuron.2018.02.018

Free article

Comment

TREM2 and Amyloid Beta: A Love-Hate Relationship

Joe Udeochu et al. Neuron. 2018.

Free article

. 2018 Mar 7;97(5):991-993.

doi: 10.1016/j.neuron.2018.02.018.

Authors

Joe Udeochu¹, Faten A Sayed², Li Gan³

Affiliations

¹ Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
² Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
³ Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA. Electronic address: lgan@gladstone.ucsf.edu.

PMID: 29518360
DOI: 10.1016/j.neuron.2018.02.018

Abstract

Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits.

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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H. Zhao Y, et al. Neuron. 2018 Mar 7;97(5):1023-1031.e7. doi: 10.1016/j.neuron.2018.01.031. Neuron. 2018. PMID: 29518356 Free PMC article.
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Lee CYD, Daggett A, Gu X, Jiang LL, Langfelder P, Li X, Wang N, Zhao Y, Park CS, Cooper Y, Ferando I, Mody I, Coppola G, Xu H, Yang XW. Lee CYD, et al. Neuron. 2018 Mar 7;97(5):1032-1048.e5. doi: 10.1016/j.neuron.2018.02.002. Neuron. 2018. PMID: 29518357 Free PMC article.

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TREM2 and Amyloid Beta: A Love-Hate Relationship

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TREM2 and Amyloid Beta: A Love-Hate Relationship

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Grants and funding

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Full Text Sources

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Medical