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Randomized Controlled Trial
. 2018 Jul;142(1):308-311.e9.
doi: 10.1016/j.jaci.2018.01.045. Epub 2018 Mar 5.

Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation?

Claudia R Morris  1 , David T Mauger  2 , Jung H Suh  3 , Wanda Phipatanakul  4 , William J Sheehan  4 , James N Moy  5 , Ian M Paul  6 , Stanley J Szefler  7 , Daniel J Jackson  8 , Anne M Fitzpatrick  9 ; National Institutes of Health/National Heart, Lung, and Blood Institute AsthmaNet
Collaborators, Affiliations
Randomized Controlled Trial

Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation?

Claudia R Morris et al. J Allergy Clin Immunol. 2018 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Baseline plasma (A) glutathione, (B) arginine and (C) ornithine concentrations (micromol/L) and erythrocyte (D) glutathione, (E) arginine, and (F) ornithine, concentrations (millimol/g hemoglobin), stratified by the number of exacerbations over 48 weeks. Circles represent individual participants; bars represent the median.
See this image and copyright information in PMC

References

    1. Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, et al. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. N Engl J Med. 2016;375:619–30. - PMC - PubMed
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    1. Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LA Severe Asthma Research P. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. J Allergy Clin Immunol. 2009;123:146–52 e8. - PMC - PubMed
    1. Morris CR, Poljakovic M, Lavisha L, Machado L, Kuypers F, Morris SM., Jr Decreased arginine bioavailability and increased arginase activity in asthma. Am J Respir Crit Care Med. 2004;170:148–53. - PubMed
    1. Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. J Am Med Assoc. 2004;294:81–90. - PMC - PubMed

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