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. 2018 Mar 7;5(1):15.
doi: 10.3390/jcdd5010015.

Oxidative DNA Damage and Carotid Intima Media Thickness as Predictors of Cardiovascular Disease in Prediabetic Subjects

Roshan Kumar Mahat  1 , Neelima Singh  2 , Akshara Gupta  3 , Vedika Rathore  4
Affiliations

Oxidative DNA Damage and Carotid Intima Media Thickness as Predictors of Cardiovascular Disease in Prediabetic Subjects

Roshan Kumar Mahat et al. J Cardiovasc Dev Dis. .

Abstract

Prediabetes is considered as a risk factor for the development of diabetes mellitus and cardiovascular disease. The present study was conducted with the aim of finding out the relationship between oxidative DNA damage and carotid intima media thickness for the prediction of cardiovascular disease in prediabetic subjects. The study included 100 prediabetic subjects and 100 normal individuals as controls. In both cases and controls, 8-OHdG was measured by ELISA, and CIMT was measured by B mode ultrasonography. Both 8-OHdG and CIMT were significantly higher in subjects with prediabetes as compared to controls (185.80 ± 10.72 pg/mL vs. 126.13 ± 16.01 pg/mL, p < 0.001 and 0.70 ± 0.04 mm vs. 0.57 ± 0.03 mm, p < 0.001, respectively). There was significant and positive correlation of IGT with 8-OHdG (r = 0.783; p < 0.001) and CIMT (r = 0.787; p < 0.001) in prediabetic subjects. Moreover, 8-OHdG showed significant positive correlation with CIMT (r = 0.704; p < 0.001) in prediabetic subjects. In conclusion, increased 8-OHdG and CIMT in prediabetic subjects indicate that biochemical changes of atherosclerosis start even before the onset of diabetes mellitus. Hence, 8-OHdG and CIMT could be used as indicators of cardiovascular disease risk in these subjects.

Keywords: 8-hydroxy-2-deoxy-guanosine; cardiovascular disease; carotid intima media thickness; prediabetes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Showing comparison of 8-OHdG between prediabetic and control subjects (data presented as mean ± SD).
Figure 2
Figure 2
Showing changes in CIMT due to impaired glucose tolerance in prediabetic subjects (data presented as mean ± SD).
Figure 3
Figure 3
Showing correlation of IGT with 8-OHdG in prediabetic subjects (r = 0.783; p < 0.001).
Figure 4
Figure 4
Showing correlation of IGT with CIMT in prediabetic subjects (r = 0.787; p < 0.001).
Figure 5
Figure 5
Showing correlation between 8-OHdG and CIMT in prediabetic subjects (r = 0.704; p < 0.001).
See this image and copyright information in PMC

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