The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

doi:10.3390/biomedicines6010030

Review

. 2018 Mar 7;6(1):30.

doi: 10.3390/biomedicines6010030.

The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

Subrat Khanal¹, Pranita Ghimire², Amit S Dhamoon³

Affiliations

¹ Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. khanals@upstate.edu.
² Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. ghimirep@upstate.edu.
³ Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. dhamoona@upstate.edu.

PMID: 29518985
PMCID: PMC5874687
DOI: 10.3390/biomedicines6010030

Review

The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

Subrat Khanal et al. Biomedicines. 2018.

. 2018 Mar 7;6(1):30.

doi: 10.3390/biomedicines6010030.

Authors

Subrat Khanal¹, Pranita Ghimire², Amit S Dhamoon³

Affiliations

¹ Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. khanals@upstate.edu.
² Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. ghimirep@upstate.edu.
³ Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. dhamoona@upstate.edu.

PMID: 29518985
PMCID: PMC5874687
DOI: 10.3390/biomedicines6010030

Abstract

Adenoviridae is a family of double-stranded DNA viruses that are a significant cause of upper respiratory tract infections in children and adults. Less commonly, the adenovirus family can cause a variety of gastrointestinal, ophthalmologic, genitourinary, and neurologic diseases. Most adenovirus infections are self-limited in the immunocompetent host and are treated with supportive measures. Fatal infections can occur in immunocompromised patients and less frequently in the healthy. Adenoviral vectors are being studied for novel biomedical applications including gene therapy and immunization. In this review we will focus on the spectrum of adenoviral infections in humans.

Keywords: adenovirus; biology; immunocompetent; immunocompromised.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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[1] Smith J.G., Wiethoff C.M., Stewart P.L., Nemerow G.R. Adenovirus. Curr. Top. Microbiol. Immunol. 2010;343:195–224. - PMC - PubMed

[2] Smith J.G., Wiethoff C.M., Stewart P.L., Nemerow G.R. Adenovirus. Curr. Top. Microbiol. Immunol. 2010;343:195–224. - PMC - PubMed

[3] Han G., Niu H., Zhao S., Zhu B., Wang C., Liu Y., Zhang M., Yang S., Liu F., Wan C., et al. Identification and typing of respiratory adenoviruses in Guangzhou, Southern China using a rapid and simple method. Virol. Sin. 2013;28:103–108. doi: 10.1007/s12250-013-3308-7. - DOI - PMC - PubMed

[4] Han G., Niu H., Zhao S., Zhu B., Wang C., Liu Y., Zhang M., Yang S., Liu F., Wan C., et al. Identification and typing of respiratory adenoviruses in Guangzhou, Southern China using a rapid and simple method. Virol. Sin. 2013;28:103–108. doi: 10.1007/s12250-013-3308-7. - DOI - PMC - PubMed

[5] Bergelson J.M., Krithivas A., Celi L., Droguett G., Horwitz M.S., Wickham T., Crowell R.L., Finberg R.W. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J. Virol. 1998;72:415–419. - PMC - PubMed

[6] Bergelson J.M., Krithivas A., Celi L., Droguett G., Horwitz M.S., Wickham T., Crowell R.L., Finberg R.W. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J. Virol. 1998;72:415–419. - PMC - PubMed

[7] Gaggar A., Shayakhmetov D.M., Lieber A. CD46 is a cellular receptor for group B adeno-viruses. Nat. Med. 2003;9:1408–1412. doi: 10.1038/nm952. - DOI - PubMed

[8] Gaggar A., Shayakhmetov D.M., Lieber A. CD46 is a cellular receptor for group B adeno-viruses. Nat. Med. 2003;9:1408–1412. doi: 10.1038/nm952. - DOI - PubMed

[9] Varga M.J., Weibull C., Everitt E. Infectious entry pathway of adenovirus type 2. J. Virol. 1991;65:6061–6070. - PMC - PubMed

[10] Varga M.J., Weibull C., Everitt E. Infectious entry pathway of adenovirus type 2. J. Virol. 1991;65:6061–6070. - PMC - PubMed

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The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

Affiliations

The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

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