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. 2018 Jan-Mar;40(1):43-49.
doi: 10.1016/j.bjhh.2017.08.006. Epub 2017 Nov 24.

Can dentists detect multiple myeloma through oral manifestations?

Thaís Miranda Xavier de Almeida  1 , Édila Figuerêdo Feitosa Cavalcanti  1 , Alessandra da Silva Freitas  1 , Roberto José Pessoa de Magalhães  1 , Angelo Maiolino  1 , Sandra Regina Torres  2
Affiliations

Can dentists detect multiple myeloma through oral manifestations?

Thaís Miranda Xavier de Almeida et al. Hematol Transfus Cell Ther. 2018 Jan-Mar.

Abstract

Objective: To review published data on oral manifestations of multiple myeloma.

Methods: An electronic database search was performed of articles published from 1971 to November 2016 in order to identify studies that reported oral manifestations of patients with multiple myeloma. Case reports and case series with oral manifestations of multiple myeloma in English were included in the study. An additional search was performed of the references of the selected articles.

Results: Thirty-seven articles that reported 81 patients with oral manifestations of multiple myeloma were selected: 30 case reports (82%) and seven case series (18%). The most common clinical features in the dental cavity were swelling (65.4%), bone pain (33.3%), paresthesia (27.1%) and amyloidosis lesions (11.1%). Osteolytic lesions detected on imaging exams were reported in the majority of the patients (90.1%) as plasmacytomas or 'punched-out' lesions.

Conclusions: Swelling and osteolytic lesions represent the most common clinical and radiographic signs of the jaws relating to multiple myeloma, respectively.

Keywords: Jaws; Mouth; Multiple Myeloma; Oral Manifestations.

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Figures

Figure 1
Figure 1
Flowchart of the study selection process.
Figure 2
Figure 2
Oral manifestations reported from the 81 individuals with multiple myeloma.
See this image and copyright information in PMC

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