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Multicenter Study
. 2018 Dec;102(12):1711-1716.
doi: 10.1136/bjophthalmol-2017-311789. Epub 2018 Mar 8.

Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Ahmet Yagmur Bas  1 , Nihal Demirel  1 , Esin Koc  2 , Dilek Ulubas Isik  3 , İbrahim Murat Hirfanoglu  2 , Turan Tunc  4 ; TR-ROP Study Group
Collaborators, Affiliations
Multicenter Study

Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Ahmet Yagmur Bas et al. Br J Ophthalmol. 2018 Dec.

Abstract

Background: To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition.

Methods: A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)≤1500 g or gestational age (GA)≤32 weeks and those with a BW>1500 g or GA>32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses.

Results: The TR-ROP study included 6115 infants: 4964 (81%) with a GA≤32 weeks and 1151 (19%) with a GA>32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW≤1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW≤1500 g. Sixty-six (16%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment.

Conclusions: Screening of infants with a GA≤34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs.

Trial registration number: NCT02814929, Results.

Keywords: Child Health (paediatrics); Neovascularisation; Retina; Treatment Medical.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Plots of BW versus GA for infants treated for ROP in three different types of NICU. (A) University hospitals. (B) State hospitals. (C) Private hospitals. BW, birth weight; GA, gestational age; NICU, neonatal intensive care unit; ROP, retinopathy of prematurity.
See this image and copyright information in PMC

References

    1. Adams GGW, Bunce C, Xing W, et al. . Treatment trends for retinopathy of prematurity in the UK. BMJ Open 2017;21:7. - PMC - PubMed
    1. Gilbert C. Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control. Early Hum Dev 2008;84:77–82. 10.1016/j.earlhumdev.2007.11.009 - DOI - PubMed
    1. Chaudhry TA, Hashmi FK, Salat MS, et al. . Retinopathy of prematurity: an evaluation of existing screening criteria in Pakistan. Br J Ophthalmol 2014;98:298–301. 10.1136/bjophthalmol-2013-304018 - DOI - PubMed
    1. Mikolajczyk RT, Zhang J, Betran AP, et al. . A global reference for fetal-weight and birthweight percentiles. Lancet 2011;377:1855–61. 10.1016/S0140-6736(11)60364-4 - DOI - PubMed
    1. Papile LA, Burstein J, Burstein R, et al. . Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529–34. 10.1016/S0022-3476(78)80282-0 - DOI - PubMed

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