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. 2018 Feb 27:11:1037-1044.
doi: 10.2147/OTT.S157378. eCollection 2018.

Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer

Xuefeng Yu #  1 , Fulan Hu #  2 , Chunfeng Li  1 , Qiang Yao  1 , Hongfeng Zhang  1 , Yingwei Xue  1
Affiliations

Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer

Xuefeng Yu et al. Onco Targets Ther. .

Abstract

Background and objectives: The dismal prognosis of gastric cancer patients is a global problem. We aim to evaluate the clinicopathologic features and prognostic factors of proximal and distal gastric cancer.

Materials and methods: Gastric cancer cases diagnosed and treated at the same surgical unit between 2007 and 2010 were reviewed. Follow-up data from all patients were collected for at least 5 years until 2015. A total of 964 patients were studied (distal gastric cancer [DG], n=777 and proximal gastric cancer [PG], n=187).

Results: DG patients had a relatively higher percentage of females, more thorough therapy (R0 [D0/D1/D2]), fewer combined organ resections, younger age, smaller tumors (<5 cm), shorter surgery durations, less blood loss during surgery, and a relatively lower percentage of nodal metastases and a TNM stage of 4 (p<0.05). A significantly higher 5-year survival rate was observed in DG patients compared to PG patients (DG: 51%, PG: 28%; p<0.001). A multivariate analysis demonstrated that tumor size, blood loss during surgery, surgery approach of lymph node dissection, treatment with palliative surgery, histopathologic type, TNM stage, and tumor location were independent predictors of poor outcome.

Conclusion: The different characteristics and prognosis of DG and PG cases have implications for the development of guiding strategies for a surgical program and assessment of prognosis of gastric cancer patients based on tumor location.

Keywords: clinicopathologic features; distal gastric cancer; gastric cancer; prognosis; proximal gastric cancer; tumor location.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The location of gastric cancers. The stomach is divided into three parts including the upper third (proximal), middle third, and lower third (distal), according to JGCA Classification of Gastric Carcinoma. Abbreviation: JGCA, Japanese Gastric Cancer Association.
Figure 2
Figure 2
Five-year survival following curative gastrectomy according to tumor location. Cumulative survival was better for patients with distal gastric cancer than proximal gastric cancer patients (p<0.001).
See this image and copyright information in PMC

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