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. 2018 Mar;94(3):129-134.
doi: 10.4174/astr.2018.94.3.129. Epub 2018 Feb 28.

Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma

Jong Man Kim  1 , Nam-Joon Yi  2 , Choon Hyuck David Kwon  1 , Kwang-Woong Lee  2 , Kyung-Suk Suh  2 , Jae-Won Joh  1
Affiliations

Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma

Jong Man Kim et al. Ann Surg Treat Res. 2018 Mar.

Abstract

Purpose: Although few hepatectomy patients develop unexpected early diffuse and multinodular recurrence in the remnant liver, the prognosis in such cases is often dismal. The aim of this study was to evaluate the risk factors of early disseminated multinodular hepatocellular carcinoma (HCC) recurrence within 3 months after liver resection for solitary HCC.

Methods: Eighty-four patients who were diagnosed with recurrent HCC within 3 months after hepatectomy for solitary HCC were retrospectively reviewed. Disseminated HCC recurrence was defined as more than 10 tumors in both lobes and total tumor size >10 cm.

Results: Preoperative α-FP level, incidence of poor tumor grade, and presence of portal vein tumor thrombosis were higher in the patients with disseminated HCC recurrence than in those without disseminated HCC recurrence (P < 0.05). Multivariate analysis showed that α-FP >1,000 ng/dL was a predisposing factor of disseminated HCC recurrence within 3 months after liver resection. The overall survival rate for patients without disseminated HCC recurrence was higher than that for patients with disseminated HCC recurrence (P < 0.001).

Conclusion: Early disseminated multinodular HCC recurrence in hepatectomy patients was associated with preoperative α-FP >1,000 ng/dL. Such patients should be frequently evaluated for the early detection of recurrent HCC for early intervention.

Keywords: Hepatectomy; Hepatocellular carcinoma; Recurrence; Survival; Tumor biomarker.

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Conflict of interest statement

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Overall survival after liver resection. HCC, hepatocellular carcinoma.
See this image and copyright information in PMC

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