Improved overall survival in head and neck cancer patients after specific therapy of distant metastases

doi:10.1007/s00405-018-4920-9

. 2018 May;275(5):1239-1247.

doi: 10.1007/s00405-018-4920-9. Epub 2018 Mar 8.

Improved overall survival in head and neck cancer patients after specific therapy of distant metastases

Dominik Schulz¹, Markus Wirth², Guido Piontek³, Andreas Knopf³, Christoph Straube^{4

5}, Steffi Pigorsch^{4

5}, Stephanie E Combs^{4

5

6}, Anja Pickhard³

Affiliations

¹ Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
² Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany. markus.wirth@tum.de.
³ Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
⁴ Department of Radiation Oncology and Radiotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
⁵ Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany.
⁶ Department of Radiation Sciences (DRS), Institute for Innovative Radiotherapy (iRT), Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

PMID: 29520497
DOI: 10.1007/s00405-018-4920-9

Improved overall survival in head and neck cancer patients after specific therapy of distant metastases

Dominik Schulz et al. Eur Arch Otorhinolaryngol. 2018 May.

. 2018 May;275(5):1239-1247.

doi: 10.1007/s00405-018-4920-9. Epub 2018 Mar 8.

Authors

Dominik Schulz¹, Markus Wirth², Guido Piontek³, Andreas Knopf³, Christoph Straube^{4

5}, Steffi Pigorsch^{4

5}, Stephanie E Combs^{4

5

6}, Anja Pickhard³

Affiliations

¹ Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
² Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany. markus.wirth@tum.de.
³ Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
⁴ Department of Radiation Oncology and Radiotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
⁵ Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany.
⁶ Department of Radiation Sciences (DRS), Institute for Innovative Radiotherapy (iRT), Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

PMID: 29520497
DOI: 10.1007/s00405-018-4920-9

Abstract

Purpose: While metastases directed therapy for oligometastatic disease is recommended in different cancer entities, the treatment of solitary metastases in head and neck squamous cell carcinoma (HNSCC) patients is not clearly defined.

Methods: A retrospective analysis was performed on data from 143 HNSCC patients treated between 2001 and 2016 in a tertiary university hospital. Clinical factors and outcome were measured using the median survival of patients receiving metastases specific therapy in comparison with matched control patients.

Results: In 37 patients, distant metastases were treated specifically with either surgery and/or stereotactic ablative radiotherapy and had with 23.97 months a more than three times higher median survival than 10 untreated matched controls with potentially treatable distant metastases (7.07 months).

Conclusions: Our retrospective analysis demonstrates a significant survival benefit for HNSCC patients who received a specific therapy regarding distant metastasis irrespective of localization as compared to a matched control cohort.

Keywords: Distant metastases; HNSCC; Overall survival; Radiotherapy; Specific treatment.

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[1] Crit Rev Oncol Hematol. 2014 Jul;91(1):47-63 - PubMed

[2] Crit Rev Oncol Hematol. 2014 Jul;91(1):47-63 - PubMed

[3] Urology. 2003 Feb;61(2):314-9 - PubMed

[4] Urology. 2003 Feb;61(2):314-9 - PubMed

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[9] Dis Colon Rectum. 2010 Jul;53(7):1080-92 - PubMed

[10] Dis Colon Rectum. 2010 Jul;53(7):1080-92 - PubMed

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Improved overall survival in head and neck cancer patients after specific therapy of distant metastases

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Improved overall survival in head and neck cancer patients after specific therapy of distant metastases

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