Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of reach and, therefore, treatment is far from ideal. Nevertheless, components involved in IBD pathogenesis including environmental, genetic, microbial, and immunological factors are continuously being investigated and the improved knowledge contributes to the development of new therapies. In this article we review the aspects of the immunopathogenesis of IBD, with focus on mucosal immunity, and discuss mechanisms of action for current and emerging biological therapies.

Keywords: Crohn’s disease; IBD; biological therapies; chronic inflammation; dysbiosis; dysregulated immune response; immunopathogenesis; ulcerative colitis.