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Case Reports
. 2018 Jun;27(7):1202-1206.
doi: 10.1177/0961203318762598. Epub 2018 Mar 9.

A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab

Y Satoh  1 , K Nakano  1 , H Yoshinari  1 , S Nakayamada  1 , S Iwata  1 , S Kubo  1 , I Miyagawa  1 , M Yoshikawa  1 , Y Miyazaki  1 , K Saito  1 , Y Tanaka  1
Affiliations
Case Reports

A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab

Y Satoh et al. Lupus. 2018 Jun.

Abstract

It has been reported that T helper 17 cells are involved in the pathogenesis of systemic lupus erythematosus, but there is no report on interleukin-17-targeted therapy. We report a case of a 62-year-old female who presented with psoriasis vulgaris and refractory lupus nephritis. Because her conditions were resistant to conventional treatment, and flow cytometry confirmed the proliferation of activated T helper 17 cells in peripheral blood, and examination of a renal biopsy tissue sample confirmed infiltration of numerous interleukin-17-positive lymphocytes to the renal interstitium, administration of the anti-interleukin-17A antibody secukinumab was initiated. After starting secukinumab the clinical and biological features were improved.

Keywords: SLE; anti-IL-17 antibody; lupus nephritis; psoriasis vulgaris; secukinumab.

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