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Review
. 2018 Mar 9;9(1):63.
doi: 10.1186/s13287-018-0791-7.

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

Somayeh Keshtkar  1   2 , Negar Azarpira  3   4 , Mohammad Hossein Ghahremani  1   5
Affiliations
Review

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

Somayeh Keshtkar et al. Stem Cell Res Ther. .

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have made them a key option for tissue repair. The paracrine functions of MSCs are applied through secreting soluble factors and releasing extracellular vesicles like exosomes and microvesicles. Extracellular vesicles are predominantly endosomal in origin and contain a cargo of miRNA, mRNA, and proteins that are transferred from their original cells to target cells. Recently it has emerged that extracellular vesicles alone are responsible for the therapeutic effect of MSCs in plenty of animal diseases models. Hence, MSC-derived extracellular vesicles may be used as an alternative MSC-based therapy in regenerative medicine. In this review we discuss MSC-derived extracellular vesicles and their therapeutic potential in various diseases.

Keywords: Extracellular vesicles; Mesenchymal stem cells; Regenerative medicine.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Origin, content, and intercellular communication of extracellular vesicles. Hsp heat shock protein, MVB multivesicular body, Tsg 101 tumor susceptibility gene 101
Fig. 2
Fig. 2
Therapeutic effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in kidney, liver, cardiovascular, and neurological diseases
See this image and copyright information in PMC

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