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Review
. 2018 Apr 19;131(16):1790-1794.
doi: 10.1182/blood-2017-11-737411. Epub 2018 Mar 9.

Hepcidin agonists as therapeutic tools

Carla Casu  1 , Elizabeta Nemeth  2 , Stefano Rivella  1
Affiliations
Review

Hepcidin agonists as therapeutic tools

Carla Casu et al. Blood. .

Abstract

Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders in which disrupted iron homeostasis causes or contributes to disease. Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these disorders.

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Conflict of interest statement

Conflict-of-interest disclosure: E.N. is a consultant and shareholder for Intrinsic LifeSciences and Silarus Therapeutics, and is a consultant for La Jolla Pharmaceutical Company, Keryx Biopharmaceuticals, and Protagonist Therapeutics. S.R. is a consultant for Ionis Pharmaceuticals. C.C. declares no competing financial interests.

References

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    1. Rechavi G, Rivella S. Regulation of iron absorption in hemoglobinopathies. Curr Mol Med. 2008;8(7):646-662. - PMC - PubMed

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