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Editorial
. 2018 Apr;29(4):1079-1081.
doi: 10.1681/ASN.2018020137. Epub 2018 Mar 9.

Evaluation of Potential Living Kidney Donors in the APOL1 Era

Barry I Freedman  1 , Bruce A Julian  2
Affiliations
Editorial

Evaluation of Potential Living Kidney Donors in the APOL1 Era

Barry I Freedman et al. J Am Soc Nephrol. 2018 Apr.
No abstract available

Keywords: APOL1; African American; chronic kidney disease; kidney donation; safety; transplantation.

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Figures

Figure 1.
Figure 1.
Higher risk of advanced CKD or ESRD in living kidney donors with the high-risk APOL1 genotype, compared to low risk genotypes.
See this image and copyright information in PMC

Comment on

  • APOL1 Genotype and Renal Function of Black Living Donors.
    Doshi MD, Ortigosa-Goggins M, Garg AX, Li L, Poggio ED, Winkler CA, Kopp JB. Doshi MD, et al. J Am Soc Nephrol. 2018 Apr;29(4):1309-1316. doi: 10.1681/ASN.2017060658. Epub 2018 Jan 16. J Am Soc Nephrol. 2018. PMID: 29339549 Free PMC article.

References

    1. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, et al. : Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329: 841–845, 2010 - PMC - PubMed
    1. Freedman BI, Skorecki K: Gene-gene and gene-environment interactions in apolipoprotein L1 gene-associated nephropathy. Clin J Am Soc Nephrol 9: 2006–2013, 2014 - PMC - PubMed
    1. Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, et al. : APOL1 genotype and kidney transplantation outcomes From deceased African American donors. Transplantation 100: 194–202, 2016 - PMC - PubMed
    1. Reeves-Daniel AM, DePalma JA, Bleyer AJ, Rocco MV, Murea M, Adams PL, et al. : The APOL1 gene and allograft survival after kidney transplantation. Am J Transplant 11: 1025–1030, 2011 - PMC - PubMed
    1. Freedman BI, Locke JE, Reeves-Daniel AM, Julian BA: Apolipoprotein L1 gene effects on kidney transplantation. Semin Nephrol 37: 530–537, 2017 - PMC - PubMed