Preservation of distal coronary perfusion during prolonged balloon inflation with an autoperfusion angioplasty catheter

Abstract

A newly designed balloon coronary angioplasty catheter that allows passive antegrade blood flow during balloon inflation (autoperfusion catheter) was compared with a standard balloon coronary angioplasty catheter. In a randomized sequence, inflations were performed for 3 min in the left circumflex coronary artery of 12 dogs with the standard catheter followed by the autoperfusion catheter or vice versa. During inflation with the standard catheter, the ST segment of standard limb lead II increased from -0.02 +/- 0.03 mV to 0.39 +/- 0.08 mV (p less than .001), whereas during inflation with the autoperfusion catheter the ST segment did not change (-0.03 +/- 0.03 vs -0.01 +/- 0.04 mV; p = NS). Regional myocardial blood flow measured by the radioactive microsphere technique in the posterior subepicardium and subendocardium was 0.12 +/- 0.03 and 0.08 +/- 0.03 ml/min/g, respectively, with the standard catheter as compared with 0.57 +/- 0.08 and 0.61 +/- 0.14 ml/min/g with the autoperfusion catheter (both p less than .01 compared with the standard catheter). Thus, unlike the standard catheter, the autoperfusion catheter allows for inflations up to 3 min in duration without producing deleterious changes in the ST segment or severe reductions in regional myocardial blood flow.