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Review
. 2018 Jun;28(2):159-169.
doi: 10.1007/s00062-018-0678-0. Epub 2018 Mar 9.

A Review of the Current Evidence on Gadolinium Deposition in the Brain

Richard Pullicino  1 , Mark Radon  2 , Shubhabrata Biswas  2 , Maneesh Bhojak  2 , Kumar Das  2
Affiliations
Review

A Review of the Current Evidence on Gadolinium Deposition in the Brain

Richard Pullicino et al. Clin Neuroradiol. 2018 Jun.

Abstract

Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies.

Keywords: Dentate nucleus; Gadolinium deposition; Gadolinium-based contrast agents; Pharmacokinetics; Regulation.

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