Plasma cell diseases and organ transplant: A comprehensive review

Abstract

Plasma cell diseases are a class of hematologic diseases that are sometimes present as preexisting diagnoses prior to organ transplantation, causative factors leading to a need for organ transplantation, or may occur posttransplant as part of the spectrum of posttransplant lymphoproliferative disorders. Herein, we review the most common plasma cell diseases, both as coexisting with other causes of organ failure, but also as a primary underlying cause for organ failure. In many cases, treatment of the underlying clonal disease may be indicated before proceeding with organ transplant. This review aims to provide current and relevant data regarding the management of these conditions in the organ transplant patient, for transplant providers, and those who take care of these patients.

Keywords: cancer/malignancy/neoplasia; clinical research/practice; heart transplantation/cardiology; hematology/oncology; kidney (allograft) function/dysfunction; kidney (native) function/dysfunction; kidney disease; kidney transplantation; kidney transplantation/nephrology; living donor.