Epidemiology and Clinical Aspects of Genetic Cardiomyopathies

Abstract

Cardiomyopathies (CMPs) are an increasingly recognized cause of heart failure and sudden death, particularly in young patients. Since their original description, major advances were achieved in the phenotype knowledge, natural history, and nosography of CMPs leading to different classification systems and therapies. However, a deeper knowledge of different causes, genotype-phenotype link, and natural history in different disease stages (preclinical, overt disease, and end-stage disease) according to a recognized standard of care (ie, international guidelines) is needed. Clinical registries can fill gaps in our knowledge regarding the uncovered issues on cause, clinical course, and management of CMPs.

Keywords: Arrhythmogenic right ventricular cardiomyopathy; Clinical registry; Hypertrophic cardiomyopathy; Nonischemic dilated cardiomyopathy; Restrictive cardiomyopathy.