[Induced drug uveitis and drug side effects in ophthalmology]

Abstract

Ocular drug side effects are very varied and can affect all the structures of the eye. The purpose of this review is to help clinicians: (i) to evoke this drug-induced toxicity yearly in the course of an unexplained ocular injury, before its damage become irreversible, (ii) to be able to recognize induced paradoxical ocular inflammation, mimicking an inflammatory pathology flare-up, especially in patient under anti-TNF regimen and (iii) to propose a more in-depth knowledge on recently described ocular toxicities from targeted cancer therapy, mainly the tyrosine kinase inhibitors.

Keywords: Anti-TNF; Cornea; Cornée; Drug-induced; Effets secondaires; Iatrogénie; Inhibiteurs des tyrosines kinases; Kerathopathy; Keratitis; Kératite; Kératopathies; Névrite optique; Ocular; Optic neuritis; Retinopathy; Rétinopathie; Side effects; Toxicity; Toxicité oculaire; Tyrosine kinase inhibitors; Uveitis; Uvéites.