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. 2018 Jan-Feb;63(1):70-72.
doi: 10.4103/ijd.IJD_728_16.

Aceclofenac-Induced Erythema Annulare Centrifugum

Dilip Meena  1 , Payal Chauhan  1 , Neirita Hazarika  1 , Naveen Kumar Kansal  1 , Arvind Gupta  2
Affiliations

Aceclofenac-Induced Erythema Annulare Centrifugum

Dilip Meena et al. Indian J Dermatol. 2018 Jan-Feb.

Abstract

Erythema annulare centrifugum (EAC) is characterised by slowly enlarging annular erythematous lesions and is thought to represent a clinical reaction pattern to infections, medications, and rarely, underlying malignancy. Causative drugs include chloroquine, cimetidine, gold sodium thiomalate, amitriptyline, finasteride, etizolam etc. We present a case of 40-year-old woman who presented to us with a 10 days history of nonpruritic, peripherally growing annular erythematous eruption. She had a history of recent onset of joint pain, for which she was taking aceclofenac 90 mg once a day for 5 days prior to the onset of the rash. This was confirmed on biopsy as EAC. The rash promptly subsided after stopping the drug. We report this case as there was no previous report of aceclofenac induced EAC.

Keywords: Aceclofenac; drug induced; erythema annulare centrifugum.

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Conflict of interest statement

There are no conflicts of interest. What is new? Acelofenac induced EAC has not been reported previously.Strong suscipion can help identify and withdraw the culprit drug.Withdrawal of the drug aids in resolution of lesions.

Figures

Figure 1
Figure 1
Erythematous annulare plaques
Figure 2
Figure 2
Trailing scales inside the advancing edges of plaques
Figure 3
Figure 3
Histopathological examination shows mild spongiosis along with superficial perivascular lymphohistiocytic infiltrate (H and E, ×100)
Figure 4
Figure 4
Close up of Figure 3 showing perivascular lymphohistiocytic infiltrate (H and E, ×400)
Figure 5
Figure 5
Clearance of lesions with hypopigmentation on back after stopping aceclofenac
Figure 6
Figure 6
Clearance of lesions over abdomen
See this image and copyright information in PMC

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