Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Feb 22:18:e10.
eCollection 2018.

Use of Hyaluronic Acid-Based Biological Bilaminar Matrix in Wound Bed Preparation: A Case Series

Richard Simman  1 , Walid Mari  1 , Sara Younes  1 , Michael Wilson  1
Affiliations

Use of Hyaluronic Acid-Based Biological Bilaminar Matrix in Wound Bed Preparation: A Case Series

Richard Simman et al. Eplasty. .

Abstract

Objectives: To analyze the efficacy of a hyaluronic acid--based matrix in the treatment of lesions where the extracellular matrix was lost. Methods: Prospective, noncomparative clinical case series. Results: Twelve patients with 12 serious surgical wounds of different etiologies participated in this project. Many defects showed exposed muscle, tendons, and/or bone. After thorough debridement, a hyaluronic acid--based matrix, with a removable, semipermeable silicone top layer, was applied for the purpose of generating a neodermis. In a number of cases, the matrix was combined with negative pressure wound therapy. All wounds developed granulation tissue. Nine wounds were subsequently closed with a split-skin autograft. There was no graft failure. Three wounds healed by secondary intention. All wounds showed complete reepithelialization. Discussion: Lesions with exposed tendon and bone are difficult to heal. Providing a granulation tissue through the use of an extracellular matrix in which cellular repopulation leads to the development of granulation tissue has been shown to be beneficial with regard to the speed and quality of healing. In this case series, the use of a hyaluronic acid--based matrix was shown to provide a granulation tissue and all lesions healed completely. Conclusion: This case series shows a strong trend for Hyalomatrix to play an important role in supporting wound healing in complex, surgical wounds.

Keywords: Hyalomatrix; extracellular matrix; healing; hyaluronic acid; wound.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Compromising factors, wound characteristics. DM indicates diabetes mellitus.
Figure 2
Figure 2
Clinical examples of lesions for which the matrix was used.
Figure 3
Figure 3
Status post disarticulation of the left hip in a 68-year-old female with a history of diabetes. Disarticulation was necessary because of extensive necrotizing fasciitis. The wound shows exposed bone.
Figure 4
Figure 4
(a-c) Clinical examples of different types of lesions.
See this image and copyright information in PMC

References

    1. Leaper DJ, Schultz G, Carville K, Fletcher J, Swanson T, Drake R. Extending the TIME concept: what have we learned in the past 10 years?(*) Int Wound J. 2012;9(suppl 2):1–19. - PMC - PubMed
    1. Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen. 2003;11(suppl 1):S1–28. - PubMed
    1. Haury B, Rodeheaver G, Vensko J, Edgerton MT, Edlich RF. Debridement: an essential component of traumatic wound care. Am J Surg. 1978;135(2):238–42. - PubMed
    1. Gfeller RW, Crowe DT. The emergency care of traumatic wounds: current recommendations. Vet Clin North Am Small Anim Pract. 1994;24(6):1249–74. - PubMed
    1. Quinby WC Jr, JF Burke, Bondoc CC. Primary excision and immediate wound closure. Intensive Care Med. 1981;7(2):71–6. - PubMed

LinkOut - more resources