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. 2018 May;29(5):740-746.
doi: 10.1111/jce.13482. Epub 2018 Apr 6.

Impact of left atrial volume, sphericity, and fibrosis on the outcome of catheter ablation for atrial fibrillation

Dennis W den Uijl  1   2 , Nuno Cabanelas  1   2 , Eva M Benito  1   2 , Rosa Figueras  1   2 , Francisco Alarcón  1   2 , Roger Borràs  1   2 , Susanna Prat  1   2 , Eduard Guasch  1   2   3 , Rosario Perea  1   2   3 , Marta Sitges  1   2   3 , Josep Brugada  1   2   3 , Antonio Berruezo  1   2   3 , Lluís Mont  1   2   3
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Impact of left atrial volume, sphericity, and fibrosis on the outcome of catheter ablation for atrial fibrillation

Dennis W den Uijl et al. J Cardiovasc Electrophysiol. 2018 May.

Abstract

Introduction: To investigate the relation between left atrial (LA) volume, sphericity, and fibrotic content derived from contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) and their impact on the outcome of catheter ablation for atrial fibrillation (AF).

Methods and results: In 83 patients undergoing catheter ablation for AF, CE-CMR was used to assess LA volume, sphericity, and fibrosis. There was a significant correlation between LA volume and sphericity (R = 0.535, P < 0.001) and between LA volume and fibrosis (R = 0.241, P = 0.029). Multivariate analyses demonstrated that LA volume was the strongest independent predictor of AF recurrence after catheter ablation (1.019, P = 0.018).

Conclusion: LA volume, sphericity, and fibrosis were closely related; however, LA volume was the strongest predictor of AF recurrence after catheter ablation.

Keywords: atrial fibrillation ablation; atrial fibrosis; atrial sphericity; cardiac magnetic resonance; left atrial volume.

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