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Multicenter Study
. 2018 Jun 1;19(6):630-638.
doi: 10.1093/ehjci/jey018.

Echocardiographic reference ranges for normal left atrial function parameters: results from the EACVI NORRE study

Tadafumi Sugimoto  1 , Sébastien Robinet  1 , Raluca Dulgheru  1 , Anne Bernard  1   2 , Federica Ilardi  1 , Laura Contu  1 , Karima Addetia  3 , Luis Caballero  4 , George Kacharava  5 , George D Athanassopoulos  6 , Daniele Barone  7 , Monica Baroni  8 , Nuno Cardim  9 , Andreas Hagendorff  10 , Krasimira Hristova  11 , Teresa Lopez  12 , Gonzalo de la Morena  4 , Bogdan A Popescu  13 , Martin Penicka  14 , Tolga Ozyigit  15 , Jose David Rodrigo Carbonero  16 , Nico van de Veire  17 , Ralph Stephan Von Bardeleben  18 , Dragos Vinereanu  19 , Jose Luis Zamorano  20 , Yun Yun Go  1 , Stella Marchetta  1 , Alain Nchimi  1 , Monica Rosca  13 , Andreea Calin  13 , Marie Moonen  1 , Sara Cimino  1 , Julien Magne  21 , Bernard Cosyns  22 , Elena Galli  23 , Erwan Donal  23 , Gilbert Habib  24   25 , Roberta Esposito  26 , Maurizio Galderisi  26 , Luigi P Badano  27 , Roberto M Lang  3 , Patrizio Lancellotti  1   28 ; NORRE Study
Collaborators, Affiliations
Free article
Multicenter Study

Echocardiographic reference ranges for normal left atrial function parameters: results from the EACVI NORRE study

Tadafumi Sugimoto et al. Eur Heart J Cardiovasc Imaging. .
Free article

Abstract

Aims: To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender.

Methods and results: A total of 371 (median age 45 years) healthy subjects were enrolled at 22 collaborating institutions collaborating in the Normal Reference Ranges for Echocardiography (NORRE) study of the European Association of Cardiovascular Imaging (EACVI). Left atrial data sets were analysed with a vendor-independent software (VIS) package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire data sets. The lowest expected values of LA function were 26.1%, 48.7%, and 41.4% for left atrial strain (LAS), 2D left atrial emptying fraction (LAEF), and 3D LAEF (reservoir function); 7.7%, 24.2%, and -0.53/s for LAS-active, LAEF-active, and LA strain rate during LA contraction (SRa) (pump function) and 12.0% and 21.6% for LAS-passive and LAEF-passive (conduit function). Left atrial reservoir and conduit function were decreased with age while pump function was increased. All indices of reservoir function and all LA strains had no difference in both gender and vendor. However, inter-vendor differences were observed in LA SRa despite the use of VIS.

Conclusion: The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function. Our data highlight the importance of age-specific reference values for LA functions.

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